Distinct brain networks associated with risk and resilience in depression

April 27, 2023

A new study that links the location of brain injury to levels of depression in patients following the injury has identified two distinct brain networks; one associated with increased depression symptoms and one associated with decreased depression symptoms. The large-scale study expands on previous findings and suggests that these brain networks might be potential targets for neuromodulation therapies to treat depression.


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A concussion is a mild traumatic brain injury. It is the physiological disruption of brain function caused by trauma that is manifested by at least one of the following: Any period of loss of consciousness; Any loss of memory for events immediately before or after the accident; Any alteration in mental state at the time of accident (e.g. feeling dazed, disoriented, or confused) Focal neurological deficit(s) that may or may not be transient. A person does not have to hit his or her head or be hit by an object. The movement of the brain inside the skull, such as in a whiplash injury, may be sufficient to cause damage.
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